MRI Scientist

A scientist with a passion for advanced analytical technologies and imaging is sought.

• The role involves utilizing preclinical MRI to solve complex issues within pharmaceutical development.
• Close collaboration with internal and external specialists from areas such as formulation development, analytical development, material science, and product performance.

What you will do.

• Develop, optimize, and validate MRI methods for pharmaceutical materials, formulations, dosage forms, and drug-delivery devices.
• Develop MRI workflows that complement CT analysis and other analytical techniques for typical pharmaceutical applications.
• Investigate water ingress and hydration kinetics in tablets, capsules, gels, and complex dosage forms to gain insight into disintegration, swelling, diffusion, and dissolution-related mechanisms, among others.
• Characterize coatings and capsules, including coating integrity, permeability, delayed release, capsule disintegration, and spatial heterogeneity of release-controlling films.
• Apply MRI to investigate the functionality of drug-delivery devices, for example, for non-destructive visualization of internal movements, fluid distribution, filling and emptying behavior, and functional performance under relevant test conditions.
• Investigate sedimentation and resuspendability of suspensions, depots, and dispersed systems by monitoring particle settling, phase separation, and redistribution after agitation.
• Translate complex imaging data into concrete and actionable insights for formulation and process development.
• Support multidisciplinary studies in formulation development, analytical development, material science, and product performance.
• Build internal expertise, standard operating procedures (SOPs), and suitable methods for data interpretation and characterization using MRI.
• Where relevant, perform and interpret basic experiments with solid-state NMR.
• Work according to all applicable environmental, health, safety, regulatory, and GMP requirements and contribute to a safe working environment.

What they ask

• Minimum of a Master's degree in physics, chemistry, or a related scientific field.
• Strong interest in advanced analytical instrumentation and experimental scientific research.
• Hands-on experience with preclinical MRI equipment is highly desired.
• Experience in interpreting imaging and/or spectroscopic data.
• Good communication skills to clearly communicate scientific results to non-specialists.
• Strong written and oral communication skills in Dutch and English.

Desirable.

• A PhD is a plus.
• Experience with solid-state NMR is a plus.
• Knowledge of organic chemistry and/or pharmaceutical materials is a plus.